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Depression Database: Genetic Factors: Transporters: SLCO1C1 (solute carrier organic anion transporter family, member 1C1)

SLCO1C1 (solute carrier organic anion transporter family, member 1C1)

Other Symbols:

OATP-F, OATP1, OATP1C1, OATPRP5, SLC21A14

Disease relevance:

This gene belongs to the organic anion transporter family. It is a thyroid hormone transporter found at the blood-brain barrier. Polymorphisms in the gene, especially OATP1C1-intron3C > T and the OATP1C1-C3035T, are related [...] http://digg.com/u1Ujew

Depression Database: Genetic Factors: Transporters: SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)

SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)

Other Symbols:

5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, hSERT

1) Disease relevance:

This gene belongs to the sodium:neurotransmitter symporter family and is incharge of transporting the neurotransmitter serotonin from synaptic spaces to presynaptic neurons. It is an important regulator of the serotonergic [...] http://digg.com/u1UXwT

Depression Database: Genetic Factors: Transporters: SLC6A3 (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3)

SLC6A3 (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3)

Other Symbols:

DAT, DAT1

1) Disease relevance:

This gene is a dopamine transporter. It belongs to the sodium- and chloride-dependent neurotransmitter transporter family. Variations in the gene are linked to idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, and susceptibility to [...] http://digg.com/u1UHxc

Depression Database: Genetic Factors: Transporters: SLC6A2 (solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2)

SLC6A2 (solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2)

Other Symbols:

NAT1, NET, NET1, SLC6A5

Disease relevance:

This gene is a member of the sodium:neurotransmitter symporter family. It is involved in the regulation of norepinephrine homeostasis and central nervous monoaminergic homeostasis. It is one of the primary targets of many antidepressants. Dysfunction [...] http://digg.com/u1UE85

Depression Database: Genetic Factors: Transporters: SLC18A1 (solute carrier family 18 (vesicular monoamine), member 1)

SLC18A1 (solute carrier family 18 (vesicular monoamine), member 1)

Other Symbols:

CGAT, VAT1, VMAT1

Disease relevance:

The vesicular monoamine transporter helps gathering cytosolic monoamines into vesicles. It is critical to the normal function of the monoaminergic systems that have been associated with human neuropsychiatric disorders. Its substrates include important drugs such as reserpine and tetrabenazine. GWA studies [...] http://digg.com/u1Tsib

Depression Database: Genetic Factors: Transporters: ABCA13 (ATP-binding cassette, sub-family A (ABC1), member 13)

ABCA13 (ATP-binding cassette, sub-family A (ABC1), member 13)

Other Symbols:

DKFZp313D2411, FLJ16398, FLJ33876, FLJ33951

Disease relevance:

This gene is belongs to the ABC gene subfamily A (ABCA) and is a lipid transporter gene. It is found to be a candidate gene in schizophrenia, bipolar disorder, and depression (Knight et al., 2009).

Sample size:

100 cases with [...] http://digg.com/u1TsiZ