"Chinese Medicine" Collateral meridian acupressure therapy relieves back pain http://buzzup.com/jaus

Immunoinformatics Databases and Tools for Microarray and Gene Expression Analyses

Name

URL

Description

RefDIC
http://ping.fm/xq5mo
Database of mRNAs and proteins of the immune system


Immunological Genome Project
http://ping.fm/7wNUp
Microarray analyses in mouse immune system


Gene Expression Omnibus (GEO)
http://ping.fm/bAZ7I
Gene expression and microarray resource


Microarray Informatics at EBI
http://ping.fm/TzIEk
Microarray data analyses


NHGRI Microarray Project
http://ping.fm/YI58A
Resources for arrays


Bibliography on Microarray Data Analysis
http://ping.fm/vbem0
Links, publications of microarray data analysis


Stanford Microarray [...] http://digg.com/u1Ge7F

Databases and Tools for Analysis of Pathways and Interactions of the Immune System

Name

URL

Description

InnateDB
http://www.innatedb.ca/
Interactions and pathways in

innate immune responses


Innate Immune Database (IIDB)
http://ping.fm/9TJc4
Genes involved with immune responses


JenPep
http://ping.fm/Z3VVB
Protein-peptide interactions in the immune system


InnateImmunity-SystemsBiology.org
http://ping.fm/L2ma3
Innate immunity, inflammation, septic shock


Pathogen Interaction Gateway (PIG)
http://ping.fm/U2mqG
Host-pathogen, protein-protein interactions


VirusMINT
http://ping.fm/wLfFF
Human-viral protein interactions


NetPath
http://www.netpath.org/
Pathways in humans, including immune pathways


KEGG
http://ping.fm/ntBJc
Pathway maps, tables, catalogs


Reactome
www.reactome.org/
A pathway database


HPRD
http://www.hprd.org/
Pathways and interaction database


GenMapp
http://www.genmapp.org/
Pathway tools


BioCyc
http://www.biocyc.org/
Pathway databases


Pathguide
http://ping.fm/6JWFL
The pathway resource [...] http://digg.com/u1Ge7E

Biomedical Standards and Terminologies for Translational Bioinformatics Studies

Name

URL

Content

Health Level Seven (HL7)
http://www.hl7.org/
Standards of health information technology


GELLO
http://ping.fm/lwB1z
A guideline query language


GuideLine Interchange Format (GLIF)
http://ping.fm/dbiXe
For sharing of clinical guidelines


Unified Medical Language System (UMLS)
http://ping.fm/Bbecx
Terminology and coding standards


Systematized Nomenclature of Medicine -Clinical Terms (SNOMED-CT)
http://ping.fm/NbOeYSnomed/snomed_main.html
A clinical terminology


International Classification of Disease (ICD)
http://ping.fm/alKQ6
Disease classifications


Current Procedural Terminology (CPT-4)
http://ping.fm/5K3qn
Terms of medical, surgical, and diagnostic services


Logical Observation Identifiers Names and Codes [...] http://digg.com/u1Ge7G

Databases and Tools for Analysis of Genetic Variations of the Immune System

Name

URL

Description

IPD
http://ping.fm/gAzEx
Immuno-polymorphism database


dbMHC
http://ping.fm/flWaj
MHC DNA and clinical


dbLRC
http://ping.fm/lpd4Z
Database of human Leukocyte Receptor Complex (LRC)


MHC Haplotype Project
http://ping.fm/60gXp
Association studies of MHC-related diseases


SNEP
http://ping.fm/p6ddS
Prediction of SNP-derived epitopes


SiPep (SNPBinder)
http://www.sipep.org/
Prediction of minor histocompatibility antigens


International HapMap Project
http://snp.cshl.org/
Databases of sequence variations


dbSNP
http://ping.fm/5lvdb
NCBI’s database of SNPs


Allele Frequencies Database
http://ping.fm/kjBKO
On alleles in human populations



http://digg.com/u1Gddm

Databases and Tools for Structure-Function Analysis of the Immune System

Name

URL

Description

IMGT®, the international ImMunoGeneTics information system®
http://imgt.cines.fr/
Database of the IG, TR, MHC, IgSF, MhcSF and RPI


ABG
http://ping.fm/sdC2M
Antibody 3D structures


Immunome
http://ping.fm/fNLG9
Immunity related proteins, structures, ontology terms


Basic Local Alignment Search Tool

(BLAST)
http://ping.fm/WhkZs
Sequence comparison


CLUSTAL W
http://ping.fm/3qI96
A tool for sequence alignment


Motif Scan
http://ping.fm/TIFwd
Finding sequence motifs/patterns


PredictProtein
http://ping.fm/hxnVK
Prediction of protein secondary structures


Protein Data Bank (PDB)
http://ping.fm/SdOk6
3D structure data


Molecular Modeling Database [...] http://digg.com/u1GdFc

Immunoinformatics Databases and Tools for T Cells, B Cells, and Epitope Analyses

Name

URL

Description

Immune Epitope Database

and Analysis Resource (IEDB)

http://ping.fm/Acr5a
Database of antibody, T cell epitopes

AntiJen Database

http://ping.fm/l4zT7
Database of peptide-MHC binding,

T, B cell epitopes, TAP

Epitome

http://ping.fm/1B3Nh
Database of antigenic epitopes

CED

http://ping.fm/rsKlj
Conformational Epitope Database

MIMOX

http://ping.fm/EDr2N
Phage display based epitope mapping

EpiJen

http://ping.fm/Qc46z
Prediction of T cell epitopes

MHCPred

http://ping.fm/ExBVs
Quantitative prediction of

peptide-MHC binding

RankPep

http://ping.fm/C7n1Q
Prediction of peptide-MHC binding

EPIMHC

http://ping.fm/kSiew
Database of [...] http://digg.com/u1GdFa

Anti-Influenza Herbs: Ginseng and Salviae

Herbs and Herbal Extracts

Ginseng and Salviae

Effects and Interactions

The herbs may have anti-influenza effects. Ginseng and Salviae may be used as potential mucosal adjuvants against influenza viruses. They may serve as immuno-modulators during influenza virus infection (Quan et al., 2007).

Mechanisms

Co-administration of influenza virus A (PR8) vaccine and ginseng or Salviae extract? may have

Enhanced [...]

http://digg.com/u1G75V

Anti-Influenza Herb: Geranium sanguineum L. (PC)

Nutrients

Polyphenols

Herbs and Herbal Extracts

The aerial roots of Geranium sanguineum L. (PC)

Effects and Interactions

The herb may have anti-influenza effects. A polyphenol-rich extract from the aerial roots of Geranium sanguineum L. (PC) has been found to protect mice from mortality in the A/Aichi/2/68 (H3N2) influenza infection (Serkedjieva et al., 2008). At the dose of 5.4 [...] http://digg.com/u1G2aA

Anti-Influenza Herb: Elsholtzia rugulosa (Lamiaceae)

Nutrients

Flavonoids

Herbs and Herbal Extracts

Flavonoids from Elsholtzia rugulosa (Lamiaceae)

General Background

It is a Chinese herb generally used for healing cold and fever.

Effects and Interactions

Flavonoids extracted from the herb have anti-influenza activities. Specifically, the herbal extract can inhibit the neuraminidase (NA) segment of influenza (Liu et al., 2008).

Reference

Liu, A. L., [...]

http://digg.com/u1FyWe

Anti-Influenza Herb: Cochinchina Momordica As A Potential Adjuvant for Influenza Vaccines

Herbs and Herbal Extracts

Crude extraction from Cochinchina momordica seeds (ECMS) through ethanol extraction.

General Background

Cochinchina momordica is a traditional Chinese medicinal herb (called ?Mu Bie Zi? in Chinese).

Effects and Interactions

Crude extraction from Cochinchina momordica seeds (ECMS) has been found to be a potential adjuvant for the improvement of the immune responses [...]

http://digg.com/u1FrRn

ABCA1 Transporter: Disease Association : Coronary Disease

ABCA1 Transporter: Disease Association:

Coronary Disease:

- The R219K polymorphism of ABCA1 is related with altered lipoprotein levels, and may affect the high-density lipoprotein-cholesterol (HDL-C) response to pravastatin in Chinese patients with coronary heart disease (CHD).

(Effect of R219K polymorphism of the ABCA1 gene on the lipid-lowering effect of pravastatin in Chinese patients with coronary heart disease. Li [...] http://digg.com/u1FoP5

Anti-infleunza Herb: Chaenomeles sinensis K (OEHNE)

Nutrients

Polyphenols

Herbal extracts

50% ethanol extract of the fruit of Chaenomeles sinensis (?Mu Gua? in Chinese)

General Background

It is a traditional Chinese medicine to treat throat diseases.

Effects and Interactions

The herbal extract may have antiviral effects. High molecular weight polyphenols in the fruit extract can inhibit influenza viruses. Treatment with the extract at concentrations higher than [...] http://digg.com/u1FmlV

ABCA1 Transporter: Tissue Distribution

ABCA1 Transporter: Tissue Distribution

Macrophages:

Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis. Brunham LR, Singaraja RR, Duong M, Timmins JM, Fievet C, Bissada N, Kang MH, Samra A, Fruchart JC, McManus B, Staels B, Parks JS, Hayden MR. Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):548-54. Epub 2009 Feb 5. PMID: 19201688

Alternate transcripts expressed in response to [...] http://digg.com/u1FjKD

Flavonoids Have Anti-influenza Effects

Flavonoids

Nutrients

Flavonoids

General Background

Flavonoids are polyphenols and commonly found in herbs. Researchers studied the structure-activity relationship (SAR) of 25 flavonoids and their effects on the neuraminidase (NA) gene of influenza virus (Liu et al., 2008). They used three typical influenza virus strains A/PR/8/34 (H1N1), A/Jinan/15/90 (H3N2), and B/Jiangshu/10/2003.

Effects and [...]

http://digg.com/u1Fj15

ABCA1 ? Polymorphisms/Variants/SNPs/Pharmacogenomics

ABCA1

Polymorphisms/Variants/SNPs/Pharmacogenomics

dbSNP

SNP VarView

GeneView in dbSNP

Prediction:

Accurate prediction of the functional significance of single nucleotide polymorphisms and mutations in the ABCA1 gene. Brunham LR, Singaraja RR, Pape TD, Kejariwal A, Thomas PD, Hayden MR. PLoS Genet. 2005 Dec;1(6):e83. Epub 2005 Dec 30. PMID: 16429166

Alzheimer?s Disease:

A novel intronic polymorphism of ABCA1 gene reveals risk for sporadic Alzheimer’s disease [...] http://digg.com/u1Ff4i

ATP-binding cassette, sub-family A (ABC1), member 1 (ABCA1)

Full Name

ATP-binding cassette, sub-family A (ABC1), member 1 [Homo sapiens]

Symbol

ABCA1

Other Symbols

ABC-1, ABC1, CERP, FLJ14958, HDLDT1, MGC164864, MGC165011, TGD

Other Names

ATP binding cassette transporter 1; ATP-binding cassette 1; ATP-binding cassette transporter A1; ATP-binding cassette, sub-family A member 1; cholesterol efflux regulatory protein; membrane-bound

Chromosome Location

9q31.1

Map Viewer

Gene ID

19

OMIM ID

600046

OMIM

Family

ATP-binding cassette, sub-family A

Classification

3.A.1.211.1

Sequences

Nucleotide

Protein

Functions

A cholesteral efflux pump

http://digg.com/u1Ff4g