Inflammation Database: genes: AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8))

AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8))

[ANHU, FLJ92595, FLJ97926, SERPINA8]

- Hyperglycemia may be related to the adverse renal effects of angiotensin II (AII). In the kidney, the glomerular mesangial cell is the main target of AII action. Glucose augments angiotensin II-induced proinflammatory gene expression in human mesangial cells (Naito et al., 2009). AII [...] http://digg.com/u1Rh2n

Inflammation Database: genes involved in inflammation: AGER (advanced glycosylation end product-specific receptor)

AGER (advanced glycosylation end product-specific receptor)

[DAMA-358M23.4, MGC22357, RAGE]

- This gene belongs to the immunoglobulin superfamily of cell surface molecules (RefSeq, 2010). Higher oxidant stress and inflammation (OS/infl) have been associated with aging-related diseases and advanced glycation end products (AGEs). AGE receptor-1 (AGER1) is an antioxidant and can reduce OS/infl. Reduction of AGEs in normal diets [...] http://digg.com/u1RbjN

Inflammation Database: genes involved in inflammation: ADORA3 (adenosine A3 receptor) – ADRB3 (adrenergic, beta-3-, receptor)

ADORA3 (adenosine A3 receptor)

[RP11-552M11.7, A3AR, AD026, bA552M11.5]

This gene is a member of the family of adenosine receptors. They are G-protein-coupled receptors that are involved in intracellular signaling pathways. This gene mediates a sustained cardioprotective effect during cardiac ischemia. It is associated with the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury.  (RefSeq, 2010)

Over-expression [...] http://digg.com/u1RVfH

Inflammation Database: genes involved in inflammation: ADIPOR1 (adiponectin receptor 1) – ADORA2A (adenosine A2a receptor)

ADIPOR1 (adiponectin receptor 1)

[ACDCR1, CGI-45, CGI45, FLJ25385, FLJ42464, PAQR1, TESBP1A]

The adiponectin receptors, ADIPOR1 and ADIPOR2 mediate elevated AMPK and PPAR-alpha ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (OMIM, 2010). In patients with chronic hepatitis C (HCV), adiponectin was found to be linked to steatosis only in males [...] http://digg.com/u1RP4G

Inflammation Database: genes involved in inflammation: ADIPOQ (adiponectin)

ADIPOQ (adiponectin, C1Q and collagen domain containing)

[ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28, adiponectin]

Total and high-molecular weight (HMW) adiponectin are correlated with markers of insulin secretion and insulinemia, endothelial function, and inflammation (Fargnoli et al., 2010).

HMW adiponectin has been found to contribute to the renal inflammation of systemic lupus erythematosus (SLE) (Song et al., [...] http://digg.com/u1QodT

Inflammation Database: genes involved in inflammation: ADAMTS13 – ADCYAP1

ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif, 13)

[C9orf8, DKFZp434C2322, FLJ42993, MGC118899, MGC118900, TTP, VWFCP, vWF-CP]

ADAMTS13 activity was found to decline with the extent of inflammatory responses (Bockmeyer et al., 2008). Systemic inflammation results in the deficiency of ADAMTS13, and such effect activates hemostasis. Thrombotic microangiopathy (TMA) is one of the sequelae of sepsis. [...] http://digg.com/u1Pm5I

Inflammation Database: genes involved in inflammation: ADA – ADAMTS10

ADA (adenosine deaminase)

Adenosine elimination on human airway epithelia is mediated by proteins including adenosine deaminase 1 (ADA1), concentrative nucleoside transporter (CNT)2, and CNT3 (Hirsh et al., 2007). These proteins are important regulators of adenosine-mediated inflammation. The study of pediatric patients with chronic hypoxia having cardiac surgery showed significant elevation in plasma adenosine deaminase (ADA) activity [...] http://digg.com/u1PeRc