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Depression Database: Genetic Factors: Transporters: SLCO1C1 (solute carrier organic anion transporter family, member 1C1)

SLCO1C1 (solute carrier organic anion transporter family, member 1C1)

Other Symbols:

OATP-F, OATP1, OATP1C1, OATPRP5, SLC21A14

Disease relevance:

This gene belongs to the organic anion transporter family. It is a thyroid hormone transporter found at the blood-brain barrier. Polymorphisms in the gene, especially OATP1C1-intron3C > T and the OATP1C1-C3035T, are related [...] http://digg.com/u1Ujew

Depression Database: Genetic Factors: Transporters: SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)

SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)

Other Symbols:

5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, hSERT

1) Disease relevance:

This gene belongs to the sodium:neurotransmitter symporter family and is incharge of transporting the neurotransmitter serotonin from synaptic spaces to presynaptic neurons. It is an important regulator of the serotonergic [...] http://digg.com/u1UXwT

Depression Database: Genetic Factors: Transporters: SLC6A3 (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3)

SLC6A3 (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3)

Other Symbols:

DAT, DAT1

1) Disease relevance:

This gene is a dopamine transporter. It belongs to the sodium- and chloride-dependent neurotransmitter transporter family. Variations in the gene are linked to idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, and susceptibility to [...] http://digg.com/u1UHxc

Depression Database: Genetic Factors: Transporters: SLC6A2 (solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2)

SLC6A2 (solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2)

Other Symbols:

NAT1, NET, NET1, SLC6A5

Disease relevance:

This gene is a member of the sodium:neurotransmitter symporter family. It is involved in the regulation of norepinephrine homeostasis and central nervous monoaminergic homeostasis. It is one of the primary targets of many antidepressants. Dysfunction [...] http://digg.com/u1UE85

Depression Database: Genetic Factors: Transporters: SLC18A1 (solute carrier family 18 (vesicular monoamine), member 1)

SLC18A1 (solute carrier family 18 (vesicular monoamine), member 1)

Other Symbols:

CGAT, VAT1, VMAT1

Disease relevance:

The vesicular monoamine transporter helps gathering cytosolic monoamines into vesicles. It is critical to the normal function of the monoaminergic systems that have been associated with human neuropsychiatric disorders. Its substrates include important drugs such as reserpine and tetrabenazine. GWA studies [...] http://digg.com/u1Tsib

Depression Database: Genetic Factors: Transporters: ABCA13 (ATP-binding cassette, sub-family A (ABC1), member 13)

ABCA13 (ATP-binding cassette, sub-family A (ABC1), member 13)

Other Symbols:

DKFZp313D2411, FLJ16398, FLJ33876, FLJ33951

Disease relevance:

This gene is belongs to the ABC gene subfamily A (ABCA) and is a lipid transporter gene. It is found to be a candidate gene in schizophrenia, bipolar disorder, and depression (Knight et al., 2009).

Sample size:

100 cases with [...] http://digg.com/u1TsiZ

Inflammation Database: genes: AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8))

AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8))

[ANHU, FLJ92595, FLJ97926, SERPINA8]

- Hyperglycemia may be related to the adverse renal effects of angiotensin II (AII). In the kidney, the glomerular mesangial cell is the main target of AII action. Glucose augments angiotensin II-induced proinflammatory gene expression in human mesangial cells (Naito et al., 2009). AII [...] http://digg.com/u1Rh2n

Inflammation Database: genes involved in inflammation: AGER (advanced glycosylation end product-specific receptor)

AGER (advanced glycosylation end product-specific receptor)

[DAMA-358M23.4, MGC22357, RAGE]

- This gene belongs to the immunoglobulin superfamily of cell surface molecules (RefSeq, 2010). Higher oxidant stress and inflammation (OS/infl) have been associated with aging-related diseases and advanced glycation end products (AGEs). AGE receptor-1 (AGER1) is an antioxidant and can reduce OS/infl. Reduction of AGEs in normal diets [...] http://digg.com/u1RbjN

Inflammation Database: genes involved in inflammation: ADORA3 (adenosine A3 receptor) – ADRB3 (adrenergic, beta-3-, receptor)

ADORA3 (adenosine A3 receptor)

[RP11-552M11.7, A3AR, AD026, bA552M11.5]

This gene is a member of the family of adenosine receptors. They are G-protein-coupled receptors that are involved in intracellular signaling pathways. This gene mediates a sustained cardioprotective effect during cardiac ischemia. It is associated with the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury.  (RefSeq, 2010)

Over-expression [...] http://digg.com/u1RVfH

Inflammation Database: genes involved in inflammation: ADIPOR1 (adiponectin receptor 1) – ADORA2A (adenosine A2a receptor)

ADIPOR1 (adiponectin receptor 1)

[ACDCR1, CGI-45, CGI45, FLJ25385, FLJ42464, PAQR1, TESBP1A]

The adiponectin receptors, ADIPOR1 and ADIPOR2 mediate elevated AMPK and PPAR-alpha ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (OMIM, 2010). In patients with chronic hepatitis C (HCV), adiponectin was found to be linked to steatosis only in males [...] http://digg.com/u1RP4G

Inflammation Database: genes involved in inflammation: ADIPOQ (adiponectin)

ADIPOQ (adiponectin, C1Q and collagen domain containing)

[ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28, adiponectin]

Total and high-molecular weight (HMW) adiponectin are correlated with markers of insulin secretion and insulinemia, endothelial function, and inflammation (Fargnoli et al., 2010).

HMW adiponectin has been found to contribute to the renal inflammation of systemic lupus erythematosus (SLE) (Song et al., [...] http://digg.com/u1QodT

Inflammation Database: genes involved in inflammation: ADAMTS13 – ADCYAP1

ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif, 13)

[C9orf8, DKFZp434C2322, FLJ42993, MGC118899, MGC118900, TTP, VWFCP, vWF-CP]

ADAMTS13 activity was found to decline with the extent of inflammatory responses (Bockmeyer et al., 2008). Systemic inflammation results in the deficiency of ADAMTS13, and such effect activates hemostasis. Thrombotic microangiopathy (TMA) is one of the sequelae of sepsis. [...] http://digg.com/u1Pm5I

Inflammation Database: genes involved in inflammation: ADA – ADAMTS10

ADA (adenosine deaminase)

Adenosine elimination on human airway epithelia is mediated by proteins including adenosine deaminase 1 (ADA1), concentrative nucleoside transporter (CNT)2, and CNT3 (Hirsh et al., 2007). These proteins are important regulators of adenosine-mediated inflammation. The study of pediatric patients with chronic hypoxia having cardiac surgery showed significant elevation in plasma adenosine deaminase (ADA) activity [...] http://digg.com/u1PeRc

Inflammation Database: genes involved in inflammation: ABCB1 – ACP5

ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1)

[ABC20, CD243, CLCS, GP170, MDR1, MGC163296, P-GP, PGY1]

In inflamed intestinal epithelium (IE) of patients with gastrointestinal disorders, MDR1 expression is significantly lower (Blokzijl et al., 2007). Reduced MDR1 levels may aggravate inflammation in the intestines.

Related diseases: Crohn’s disease (CD), ulcerative colitis (UC), diverticulitis, collagenous colitis.

Reference:

Blokzijl, H., Vander Borght, [...] http://digg.com/u1Nsjb

Stroke: symptoms, types, risk factors, and prevention

What is stroke: symptoms, types, and risk factors

Stroke is one of the leading causes of death in the US. Stroke is also called a “brain attack.” Similar to heart attack, stroke happens when the blood flow to part of the brain is blocked. The brain cells may be damaged or die when they cannot get [...] http://digg.com/u1N1ba

Hypertension: diagnosis, risk factors, and prevention

What is hypertension: symptoms, diagnosis, and risk factors

Only about half of people having hypertension are treated, and more than 30 percent of those who have hypertension do not know it. The force of blood against vessel walls is blood pressure. When the heart contracts, the blood pressure measured is called systolic pressure. When the heart [...] http://digg.com/u1MtsP

Heart disease: symptoms, diagnosis, risk factors, and prevention

What is heart disease: symptoms, diagnosis, and risk factors

Heart disease is the first leading cause of death in the US, accounting for about 500,000 sudden deaths each year. It is also called coronary artery disease. Heart disease is caused by the accumulation of fatty deposits, the cholesterol plaque in the coronary arteries. Coronary arteries bring [...] http://digg.com/u1Mt0T

Gum disease, gingivitis, and periodontitis: symptoms and prevention

What is gum disease: symptoms and related factors

Gum disease is also called periodontal disease. It is caused by the accumulation of plaques between the gums and teeth. The plaques are sticky substances containing bacteria. Gingivitis is a mild gum disease with swollen and red gums that may bleed easily, often accompanied with bad breath.

Gingivitis is [...] http://digg.com/u1Mn6P

Gout: symptoms, types, and prevention

What is gout: symptoms and types

Gout is a type of arthritis that may show symptoms as intense and burning pain, stiffness, and tenderness in joints which are hot, red, and swollen. It can usually be seen in joints with osteoarthritis. Gouts may occur when the kidney is abnormal in excreting uric acid, which is generated [...] http://digg.com/u1Mj4J