Anti-Influenza Herb: Cochinchina Momordica As A Potential Adjuvant for Influenza Vaccines

Herbs and Herbal Extracts

Crude extraction from Cochinchina momordica seeds (ECMS) through ethanol extraction.

General Background

Cochinchina momordica is a traditional Chinese medicinal herb (called ?Mu Bie Zi? in Chinese).

Effects and Interactions

Crude extraction from Cochinchina momordica seeds (ECMS) has been found to be a potential adjuvant for the improvement of the immune responses [...]

http://digg.com/u1FrRn

ABCA1 Transporter: Disease Association : Coronary Disease

ABCA1 Transporter: Disease Association:

Coronary Disease:

- The R219K polymorphism of ABCA1 is related with altered lipoprotein levels, and may affect the high-density lipoprotein-cholesterol (HDL-C) response to pravastatin in Chinese patients with coronary heart disease (CHD).

(Effect of R219K polymorphism of the ABCA1 gene on the lipid-lowering effect of pravastatin in Chinese patients with coronary heart disease. Li [...] http://digg.com/u1FoP5

Anti-infleunza Herb: Chaenomeles sinensis K (OEHNE)

Nutrients

Polyphenols

Herbal extracts

50% ethanol extract of the fruit of Chaenomeles sinensis (?Mu Gua? in Chinese)

General Background

It is a traditional Chinese medicine to treat throat diseases.

Effects and Interactions

The herbal extract may have antiviral effects. High molecular weight polyphenols in the fruit extract can inhibit influenza viruses. Treatment with the extract at concentrations higher than [...] http://digg.com/u1FmlV

ABCA1 Transporter: Tissue Distribution

ABCA1 Transporter: Tissue Distribution

Macrophages:

Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis. Brunham LR, Singaraja RR, Duong M, Timmins JM, Fievet C, Bissada N, Kang MH, Samra A, Fruchart JC, McManus B, Staels B, Parks JS, Hayden MR. Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):548-54. Epub 2009 Feb 5. PMID: 19201688

Alternate transcripts expressed in response to [...] http://digg.com/u1FjKD

Flavonoids Have Anti-influenza Effects

Flavonoids

Nutrients

Flavonoids

General Background

Flavonoids are polyphenols and commonly found in herbs. Researchers studied the structure-activity relationship (SAR) of 25 flavonoids and their effects on the neuraminidase (NA) gene of influenza virus (Liu et al., 2008). They used three typical influenza virus strains A/PR/8/34 (H1N1), A/Jinan/15/90 (H3N2), and B/Jiangshu/10/2003.

Effects and [...]

http://digg.com/u1Fj15

ABCA1 ? Polymorphisms/Variants/SNPs/Pharmacogenomics

ABCA1

Polymorphisms/Variants/SNPs/Pharmacogenomics

dbSNP

SNP VarView

GeneView in dbSNP

Prediction:

Accurate prediction of the functional significance of single nucleotide polymorphisms and mutations in the ABCA1 gene. Brunham LR, Singaraja RR, Pape TD, Kejariwal A, Thomas PD, Hayden MR. PLoS Genet. 2005 Dec;1(6):e83. Epub 2005 Dec 30. PMID: 16429166

Alzheimer?s Disease:

A novel intronic polymorphism of ABCA1 gene reveals risk for sporadic Alzheimer’s disease [...] http://digg.com/u1Ff4i

ATP-binding cassette, sub-family A (ABC1), member 1 (ABCA1)

Full Name

ATP-binding cassette, sub-family A (ABC1), member 1 [Homo sapiens]

Symbol

ABCA1

Other Symbols

ABC-1, ABC1, CERP, FLJ14958, HDLDT1, MGC164864, MGC165011, TGD

Other Names

ATP binding cassette transporter 1; ATP-binding cassette 1; ATP-binding cassette transporter A1; ATP-binding cassette, sub-family A member 1; cholesterol efflux regulatory protein; membrane-bound

Chromosome Location

9q31.1

Map Viewer

Gene ID

19

OMIM ID

600046

OMIM

Family

ATP-binding cassette, sub-family A

Classification

3.A.1.211.1

Sequences

Nucleotide

Protein

Functions

A cholesteral efflux pump

http://digg.com/u1Ff4g